A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro.

نویسندگان

  • Ali Ali El-Gamal
  • Mohamed Farag Abd-El-Halim
  • Ashraf Taha Kalil
  • Omer Ahmed Basudan
  • Adnan Jathlan Al-Rehaily
  • Mohamed Shamim Ahmad
  • Kamal Hussin El-Tahir
  • Shaza Mohamed Al-Massarani
  • Wael Moustafa Abdel-Mageed
چکیده

A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.

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عنوان ژورنال:
  • Pakistan journal of pharmaceutical sciences

دوره 28 2 Suppl  شماره 

صفحات  -

تاریخ انتشار 2015